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Moreover, levels of malondialdehyde (MDA), a reactive carbonyl compound and a major end product of lipid oxidation, also did not increase significantly post-prandially after selenium supplementation, while prior to supplementation MDA plasma levels increased by about 10 per cent.
"Our results, obtained on subjects adequately supplied with selenium, suggest that a non-limiting selenium availability counteracts the postprandial formation of the atherogenic form of LDL and provide a rationale for the epidemiological evidence of the inverse correlation between selenium intake and the incidence of chronic and degenerative diseases," said Natella.
The study does have an obvious limitation in that no placebo group was used for comparison, and further studies are required to confirm the benefits of improved selenium status for a reduced risk of cardiovascular disease.
European selenium levels have been falling since the EU imposed levies onwheat imports from the US, where soil selenium levels are high. As a result, average intake of selenium in the UK has fallen from 60 to 34 micrograms per day, leading to calls from some to enrich soil and fertilizers with selenium to boost public consumption.
Source: Nutrition, Metabolism and Cardiovascular Diseases
Published on-line ahead of print, doi: 10.1016/j.numecd.2006.05.002
"Selenium supplementation prevents the increase in atherogenic electronegative LDL (LDL minus) in the postprandial phase"
Authors: F. Natella, M. Fidale, F. Tubaro, F. Ursini and C. Scaccini